Diagnosis of Endogenous Hyperinsulinism (2) In infants below the age of two years, insulin-secreting tumours are so rare that either functional hyperinsulinism (nesidioblastosis) or malicious sulphonylurea administration must be considered the likely cause of endogenous hyperinsulinism. See later: • Fasting Hypoglycaemia Test • ‘Inappropriate’ Insulin Secretion • Plasma Proinsulin Assay • Plasma C-Peptide Assay • Localisation of Insulinomas See also: • Nesidioblastosis • Treatment of Endogenous Hyperinsulinism